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The role of local dynamics and global network structure in seizure generation unveiled!

17th November 2014

Researchers on the MRC and Epilepsy Research UK funded Epilepsy research programme at the University of Exeter and King's College London have published findings demonstrating that the interplay between the dynamics of brain regions and the global structures connecting them can enhance susceptibility to seizures. The results published in PLoS Computational Biology last week, show that, in people with epilepsy whose functional brain networks show abnormalities in comparison to healthy controls, dynamic changes in specifc brain regions can naturally lead to the generation of seizures. This computational modelling approach has demonstrated the potential for resting state data to be used for the purposes of diagnosis of epilepsy, where the probability of seizures arising from networks of people with epilepsy is much greater, than the corresponding values in control groups.

The full paper is available here.

 

 

Associated projects: 
Epilepsy Programme